ABILITIES OF DIFFERENTIATION AND PARTIAL LEAST-SQUARES METHODS IN THEANALYSIS BY DIFFERENTIAL-PULSE POLAROGRAPHY - SIMULTANEOUS DETERMINATION OF FURAZOLIDONE AND FURALTADONE

A comparison between the applicability of two multicomponent analysis methods, differentiation of signals and partial least squares (PLS) me thods, to the resolution of overlapping differential pulse polarograph ic (DPP) peaks corresponding to the irreversible reduction process of two nitrofuran derivatives has been performed. The results show that t he derivative DPP signals are not suitable for the resolution of mixtu res of these system, by application of the zero-crossing method, becau se the zero-crossing potential is not independent of the concentration . However, PLS has the capacity of modelling the total evolution of th e DPP peaks with the concentration. The PLS multivariate calibration m ethod has been successfully applied to the simultaneous analysis of bo th compounds in a pharmaceutical formulation.