DETERMINATION OF OXELADIN IN HUMAN PLASMA BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY

A capillary gas chromatographic method with mass-selective detection w as developed for the determination of oxeladin in human plasma. Plasma samples (1 mL) were alkalinized and extracted using 5 mt of hexane:is oamyl alcohol (99:1). The method was demonstrated to he sensitive (lim it of quantitation at 1 ng/mL), linear between 1 and 150 mg/mL, accura te and precise enough (mean error and mean coefficient of variation at the limit of quantitation were 2.3 and 13.3%, respectively) to suppor t pharmacokinetic evaluation of the drug at doses down to 30 mg.