TRANSFORMATION OF CONGENITAL NEUTROPENIA INTO MONOSOMY-7 AND ACUTE NONLYMPHOBLASTIC LEUKEMIA IN A CHILD TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR
Me. Weinblatt et al., TRANSFORMATION OF CONGENITAL NEUTROPENIA INTO MONOSOMY-7 AND ACUTE NONLYMPHOBLASTIC LEUKEMIA IN A CHILD TREATED WITH GRANULOCYTE-COLONY-STIMULATING FACTOR, The Journal of pediatrics, 126(2), 1995, pp. 263-265
A cytogenetically normal infant with Kostmann syndrome (severe congeni
tal granulocytopenia) was treated with granulocyte colony-stimulating
factor, which resulted in a rapid improvement in his neutrophil count
and a resolution of recurrent infections, After 11 months of therapy,
splenomegaly developed, with thrombocytopenia, anemia, circulating nuc
leated erythrocytes, and acquired monosomy 7, which evolved during a p
eriod of 7 months into acute nonlymphoblastic leukemia, The use of gra
nulocyte colony-stimulating factor in patients with congenital marrow
failure disorders may induce or hasten the onset of a malignant transf
ormation.