GLIBENCLAMIDE, A BLOCKER OF ATP-SENSITIVE POTASSIUM CHANNELS, REVERSES ENDOTOXIN-INDUCED HYPOTENSION IN PIG

Citation
G. Vanelli et al., GLIBENCLAMIDE, A BLOCKER OF ATP-SENSITIVE POTASSIUM CHANNELS, REVERSES ENDOTOXIN-INDUCED HYPOTENSION IN PIG, Experimental physiology, 80(1), 1995, pp. 167-170
Citations number
8
Categorie Soggetti
Physiology
Journal title
ISSN journal
09580670
Volume
80
Issue
1
Year of publication
1995
Pages
167 - 170
Database
ISI
SICI code
0958-0670(1995)80:1<167:GABOAP>2.0.ZU;2-Z
Abstract
In anaesthetized, mechanically ventilated, indomethacin-treated pigs, we infused E. coli endotoxin (LPS, 20 mu g kg(-1) h(-1), I.V.). After 150 min of endotoxaemia, 10 mg kg(-1) glibenclamide (an ATP-sensitive KC channel antagonist) was administered I.V. over 5 min. Vascular vari ables were recorded before (control), after 150 min of endotoxaemia an d 5, 15 and 30 min after glibenclamide infusion. Glibenclamide transie ntly (within 5 min) increased systemic arterial pressure, reduced by L PS administration, without an effect on cardiac output. Our data indic ate that ATP-sensitive K+ channels may play a partial role in the vasc ular changes due to endotoxaemia.