Paclitaxel is a new antimitotic derived from yew-tree, used for the tr
eatment of ovarian and breast cancers. The local toxicity of paclitaxe
l is still poorly known. We report one of the first observations of ac
cidental subcutaneous extravasation of paclitaxel. Local epidermic nec
rosis was observed and evolution was good with local treatment only. T
reatments of such extravasation are discussed.