A THEOREM RELATING CROSS-RELAXATION AND HARTMANN-HAHN TRANSFER IN MULTIPLE-PULSE SEQUENCES - OPTIMAL SUPPRESSION OF TOCSY TRANSFER IN ROESY

By use of average-Hamiltonian theory and invariant-trajectory approach es, a theorem is derived that relates cross relaxation and Hartmann-Ha hn transfer during multiple-pulse sequences. The result is used to obt ain an expression for the theoretical minimum of coherence transfer th at must be accepted in ROESY experiments. Jump-symmetrized CW-ROESY se quences are proposed that approach optimal suppression of TOCSY transf er combined with excellent offset behavior of the effective cross-rela xation rate. The results are demonstrated using numerical simulations and experimental spectra of a disaccharide. (C) 1995 Academic Press, I nc.