Background: The ocular hypertensive response to corticosteroids is wel
l established. Elevated intraocular pressure (IOP) secondary to cortic
osteroids by nasal spray or inhalation has rarely been reported. Resul
ts: Three patients showed a possible ocular hypertensive response to b
eclomethasone dipropionate by nasal spray or inhalation. In two patien
ts, the IOP returned to pretreatment levels after discontinuing nasal
corticosteroid spray. One patient required medication to control IOP w
ith continued inhaled corticosteroid. One patient later demonstrated a
n ocular hypertensive response to oral steroids. Conclusion: Corticost
eroids by nasal spray or inhalation may cause ocular hypertension in s
usceptible patients. The authors recommend surveillance of IOP in pati
ents using these medications.