The aim of this investigation was to study the accuracy of a newly dev
eloped electrical resistance monitor in diagnosing occlusal fissure ca
ries in vivo in teeth without cavitation. The electrical resistance wa
s measured in vivo on human third molars without existing restorations
and without any macroscopic carious cavitation. Data from 41 sites on
26 occlusal surfaces were obtained. After measurement, the teeth were
extracted, histologically prepared, and serially sectioned perpendicu
lar to the occlusal surface and examined for the presence of caries. N
ineteen sites had no caries, 7 had enamel caries, and 15 sites showed
dentinal caries, 4 of which deep dentinal caries. For the diagnosis of
occlusal caries with the electrical resistance monitor, the specifici
ty was 0.77, the sensitivity 0.93, and the accuracy 0.83. Likelihood r
atios for four diagnostic levels (no caries, enamel caries, dentinal c
aries, and deep dentinal caries) were 0.09, 0, 3.47, and 4.16, respect
ively. Diagnosis of occlusal caries using conventional bite-wing radio
graphs showed a specificity of 0.77, a sensitivity of 0.62, and an acc
uracy of 0.71. The electrical resistance monitor was well suited to de
tect in vivo occlusal caries under clinically intact fissures. The rat
her high value (0.23) of false-positive ratings, however, might lead t
o a substantial number of sound teeth being restored unnecessarily. Su
bstantial improvement of occlusal caries diagnosis may be achieved by
combining this method with others.