Objective: To measure any sex size differences in the bony nasolacrima
l drainage Systems in a normal, age-matched population. Methods: A ret
rospective study of axial cut maxillofacial computed tomographic scans
was conducted. Three levels of the bony nasolacrimal duct (NLD) syste
m on the right and left sides were measured along the anteroposterior
diameter. The data were analyzed using 2-tail t test, analysis of vari
ance, and linear regression methods. Results: Scans from 71 adult pati
ents (36 men and 35 women) were reviewed. Women were found to have a s
maller bony diameter at the level of the lower fossa (P=.01) and the m
iddle NLD (P=.06) compared with those of men. The adult inferior bony
fossa increased in size with age in both men and women, while the midd
le NLD increased in size in men only. No significant size difference w
as found between the right and left side at any level. Conclusions: Si
ze differences are found in measurements of bony nasolacrimal excretor
y systems in men vs women. Women have significantly smaller dimensions
in the lower nasolacrimal fossa and the middle NLD. The anteroposteri
or dimension of the bony nasolacrimal canal at the fossa level enlarge
d in both sexes, with age coinciding with osteoporotic changes through
out the body. These quantitative anatomical observations preside a con
tributory factor to explain the increased prevalence of primary acquir
ed NLD obstruction in women.