We review our experience of transbronchial fine needle aspiration (TBF
NA) over a 3-year period. A total of 112 TBFNAs were performed on 95 p
atients. Four aspirates were from peripheral lung lesions, 20 from non
-ulcerated submucosal infiltrative lesions, 19 from mediastinal abnorm
alities close to the tracheobronchial tree, and the remaining 69 were
for staging of bronchogenic carcinoma with apparent mediastinal lymph
node spread, evaluated by chest computed tomography (CT). In the 20 su
bmucosal lesions TBFNA reached a sensitivity of 82.3%, providing the o
nly evidence of a malignant process in five cases. With respect to the
19 mediastinal lesions arising in close proximity to the central airw
ays, TBFNA permitted a diagnosis in cases that would otherwise have re
quired more invasive procedures, although the diagnostic sensitivity o
f the technique in this group of patients was poor (26%). In the media
stinal staging group, the sensitivity was 76.9%, with no false positiv
e results. Complete sensitivity of TBFNA for the detection of disease
was 65.8%. We conclude that TBFNA is a reliable and low risk procedure
.