TOOLS FOR COMBINATORIAL CHEMISTRY - IN-SITU INFRARED-ANALYSIS OF SOLID-PHASE ORGANIC-REACTIONS

Methodology for in situ infrared monitoring and analysis of solid-phas e organic reactions has been developed. The real-time, single-bead cap abilities of this technique are illustrated through the analysis of so lvent diffusion into, and subsequent wash-out from, a 70-mu m aminomet hyl polystyrene bead. This report further illustrates application of t his technology for solid-phase synthesis with real-time analysis using two example reactions. Analytical hardware and the inherent benefits of real-time analysis with respect to precursor referencing and the qu ality, utility, and interpretation of the infrared data are also discu ssed.