NOVEL CA2-ATPASE INHIBITORS FROM THE DRIED ROOT TUBERS OF POLYGONUM-MULTIFLORUM()

Authors
GRECH JN LI Q ROUFOGALIS BD DUKE CC
Citation
Jn. Grech et al., NOVEL CA2-ATPASE INHIBITORS FROM THE DRIED ROOT TUBERS OF POLYGONUM-MULTIFLORUM(), Journal of natural products, 57(12), 1994, pp. 1682-1687
Citations number
26
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
12
Year of publication
1994
Pages
1682 - 1687
Database
ISI
SICI code
0163-3864(1994)57:12<1682:NCIFTD>2.0.ZU;2-#
Abstract
The MeOH extract of the dried root tubers of Polygonum multiflorum yie lded three bioactive compounds with an inhibitory activity on calmodul in-depleted erythrocyte calcium-dependent ATPase. These compounds were identified as E-2,3,5,4'-tetrahydroxystilbene 2-O-beta-D-glucopyranos ide [2] (IC50=240 mu M) and cis- and ,7-tetrahydro-6,7-dihydroxy-1(3H) -isobenzofuranone [3 and 4] (IC50=160 and 260 mu M, respectively). E-2 ,4,6,4'-Tetrahydroxystilbene 2-O-beta-D-glucopyranoside [1] was also i solated but was found to have no inhibitory effect on the enzyme.