OPHIRAPSTANOL TRISULFATE, A NEW BIOLOGICALLY-ACTIVE STEROID SULFATE FROM THE DEEP-WATER MARINE SPONGE TOPSENTIA OPHIRAPHIDITES

Authors
GUNASEKERA SP SENNETT SH KELLYBORGES M BRYANT RW
Citation
Sp. Gunasekera et al., OPHIRAPSTANOL TRISULFATE, A NEW BIOLOGICALLY-ACTIVE STEROID SULFATE FROM THE DEEP-WATER MARINE SPONGE TOPSENTIA OPHIRAPHIDITES, Journal of natural products, 57(12), 1994, pp. 1751-1754
Citations number
12
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
57
Issue
12
Year of publication
1994
Pages
1751 - 1754
Database
ISI
SICI code
0163-3864(1994)57:12<1751:OTANBS>2.0.ZU;2-O
Abstract
Ophirapstanol trisulfate [1], a new steroid trisulfate related to soko trasterol trisulfate was isolated from a deep water marine sponge Tops entia ophiraphidites. Compound 1 exhibited significant inhibition in t he guanosine diphosphate/G-protein RAS exchange assay. The structure e lucidation of 1 and ophirapstanol [2] by nmr spectroscopy is described .