PROTON MAGNETIC-RESONANCE SPECTROSCOPIC IMAGING IN PATIENTS WITH FRONTAL-LOBE EPILEPSY

Proton magnetic resonance spectroscopic imaging (H-1 MRSI) has demonst rated decreased N-acetyl compounds (NA) in the epileptogenic hippocamp us in patients with temporal lobe epilepsy. We studied 8 patients with frontal lobe epilepsy and found mean NA/creatine (Cr) in the epilepto genic frontal lobe decreased by 27% compared with that of the contrala teral homologous region (1.81 +/- 0.36 vs 2.49 +/- 0.60, p < 0.008). I n every patient, NA/Cr was decreased in the epileptogenic region by at least 5%. These findings suggest that H-1 MRSI may be useful in the p resurgical evaluation of patients with frontal lobe epilepsy.