EFFECT OF PROPYLENE-GLYCOL 1,2-DINITRATE ON CEREBRAL BLOOD-FLOW IN RATS - A POTENTIAL BIOMARKER FOR VASCULAR HEADACHE

Two measurable indices of toxicity that can be correlated with exposur e to propylene glycol dinitrate (PGDN) were evaluated along with its m etabolism. Propylene glycol dinitrate was administered by rapid i.v. i njection to male Fischer-344 rats. These rats demonstrated a dose-resp onse of blood pressure (BP) to doses of PGDN ranging from 0.1 to 30 mg /kg; the maximum fall in systolic BP occurred within 1 min of dosing, The i.v. administration of PGDN to separate groups of animals resulted in an increase in cerebral blood flow that was correlated with the do se, but a clear dose-response was not obtained.