SYNTHESIS OF MORPHINE-6-GLUCURONIDE VIA A HIGHLY SELECTIVE ENZYME-CATALYZED HYDROLYSIS REACTION

Authors
BROWN RT CARTER NE SCHEINMANN F TURNER NJ
Citation
Rt. Brown et al., SYNTHESIS OF MORPHINE-6-GLUCURONIDE VIA A HIGHLY SELECTIVE ENZYME-CATALYZED HYDROLYSIS REACTION, Tetrahedron letters, 36(7), 1995, pp. 1117-1120
Citations number
6
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
7
Year of publication
1995
Pages
1117 - 1120
Database
ISI
SICI code
0040-4039(1995)36:7<1117:SOMVAH>2.0.ZU;2-B
Abstract
Morphine-6-glucuronide 1, a patent analgesic, has been prepared from m orphine-3,6-diglucuronide 3 via a highly selective hydrolytic cleavage of the phenolic 3-glucuronide group using beta-glucuronidase as catal yst.