DIFFERENTIATION OF FOLLICULAR LYMPHOMA-CELLS AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION AND HEMATOPOIETIC GROWTH-FACTOR TREATMENT

Authors
KRAMER MHH KLUIN PM WIJBURG ER FIBBE WE KLUINNELEMANS HC
Citation
Mhh. Kramer et al., DIFFERENTIATION OF FOLLICULAR LYMPHOMA-CELLS AFTER AUTOLOGOUS BONE-MARROW TRANSPLANTATION AND HEMATOPOIETIC GROWTH-FACTOR TREATMENT, Lancet, 345(8948), 1995, pp. 488-490
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
Lancet → ACNP
ISSN journal
01406736
Volume
345
Issue
8948
Year of publication
1995
Pages
488 - 490
Database
ISI
SICI code
0140-6736(1995)345:8948<488:DOFLAA>2.0.ZU;2-E
Abstract
A patient with follicular lymphoma developed a striking but transient plasmacytosis in blood and bone marrow with paraproteinaemia after tre atment by autologous bone marrow transplantation and interleukin-3 (IL -3). By immunophenotyping, cytogenetics and Southern blotting, we prov ed that the plasma cells were clonally related to the original lymphom a cells. This event was preceded by fever accompanied by high IL-6 con centrations. The patient recovered spontaneously and had a long-lastin g remission. We speculate that the bone marrow-derived malignant B cel ls were stimulated by IL-3 and IL-6 into terminally differentiated pla sma cells.