DEFECTIVE MATURATION AND FUNCTION OF ANTIGEN-PRESENTING CELLS IN TYPE-1 DIABETES

Citation
A. Jansen et al., DEFECTIVE MATURATION AND FUNCTION OF ANTIGEN-PRESENTING CELLS IN TYPE-1 DIABETES, Lancet, 345(8948), 1995, pp. 491-492
Citations number
10
Categorie Soggetti
Medicine, General & Internal
Journal title
LancetACNP
ISSN journal
01406736
Volume
345
Issue
8948
Year of publication
1995
Pages
491 - 492
Database
ISI
SICI code
0140-6736(1995)345:8948<491:DMAFOA>2.0.ZU;2-X
Abstract
Macrophages and dendritic cells are important as antigen-presenting ce lls in the islet autoimmune response. We report decreased maturation o f dendritic cells from blood monocytes of 61 patients with type 1 diab etes compared with 31 healthy controls (medians 26 and 35%, respective ly, p=0.0005). The dendritic cells also had reduced ability to cluster (96 and 124 clusters, respectively, p=0.0005), and to stimulate autol ogous and allogeneic T cells. Because optimum antigen presentation is primarily required for tolerance induction rather than for immunisatio n, the defective maturation and function of diabetic dendritic cells m ight be the basis for disturbed activation of regulatory (suppressor) T cells.