RELATIONSHIP BETWEEN SOME HUMORAL-FACTORS AND LEFT-VENTRICULAR HYPERTROPHY IN ESSENTIAL-HYPERTENSION

Objective. To evaluate the relationship between certain humoral factor s and left ventricular hypertrophy (LVH) in essential hypertension. Pa tients and Methods. 62 essential hypertension (EH) patients (32 men, 3 0 women; mean age, 55 years) and 20 normotensive healthy subjects (10 men, 10 women; mean age, 52 years) were studied. EH patients were divi ded into LVH group and non-LVH group by echocardiography. After an ove rnight fast, blood samples were taken for the determination of parathy roid hormone (PTH), angiotensin II (ATII) and aldosterone (ALD) by rad ioimmunoassay. Results. There was a significant difference in PTH, AT II and ALD between the EH group and control group. Furthermore, in LVH group PTH, ATII and ALD elevated significantly as compared with non-L VH group. In addition, we found that LVMI (left ventricular mass index ) correlated with ATII (r=0.342, P<0.01) and ALD (r=0.356, P<0.01). Th ere was a more significant correlation between LVMI and PTH (r=0.422, P<0.0025). Conclusions. Some humoral factors are important determinant s of LV mass. Besides the renin-angiotensin-aldosterone system, PTH mi ght play an important role in cardiac hypertrophy.