Sl. Opsjon et al., INTERLEUKIN-1, INTERLEUKIN-6 AND TUMOR-NECROSIS-FACTOR AT DELIVERY INPREECLAMPTIC DISORDERS, Acta obstetricia et gynecologica Scandinavica, 74(1), 1995, pp. 19-26
Background. To examine if preeclamptic disorders lead to altered conce
ntrations of tumor necrosis factor, interleukin-1 and interleukin-6 at
delivery compared to normal pregnancy. Methods. Amniotic fluid, place
nta, maternal and cord serum were collected at delivery by cesarean se
ction or spontaneous labor. Samples were retrieved from 53 women with
normal pregnancy, 54 with preeclamptic disorders and 15 who delivered
a small for gestational neonate of unknown cause. Cytokines were measu
red by bioassays. Statistics were performed with nonparametric tests.
Results. Interleukin-1 in amniotic fluid tended to be lower with preec
lamptic disorders than in normal pregnancy irrespective of labor. Ther
e was an increase in amniotic fluid tumor necrosis factor, interleukin
-1 and interleukin-6 with onset of labor in preeclamptic disorders jus
t as in normal pregnancy. There was a similar increase in interleukin-
6 in cord and maternal serum in the same groups, even if concentration
of interleukin-6 in cord serum in labor of preeclamptic disorders was
lower than in normal pregnancy. Conclusions. No major differences wer
e seen in concentrations of interleukin-1, interleukin-6 and tumor nec
rosis factor in amniotic fluid, placenta, maternal or cord serum at de
livery with preeclamptic disorders compared to normal pregnancy.