RELATIVE BIOAVAILABILITY OF A NEW ORAL FORM OF CYCLOSPORINE-A IN PATIENTS WITH RHEUMATOID-ARTHRITIS

Authors
VANDENBORNE BEEM LANDEWE RBM THE HSG MATTIE H BREEDVELD FC DIJKMANS BAC
Citation
Beem. Vandenborne et al., RELATIVE BIOAVAILABILITY OF A NEW ORAL FORM OF CYCLOSPORINE-A IN PATIENTS WITH RHEUMATOID-ARTHRITIS, British journal of clinical pharmacology, 39(2), 1995, pp. 172-175
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British journal of clinical pharmacology → ACNP
ISSN journal
03065251
Volume
39
Issue
2
Year of publication
1995
Pages
172 - 175
Database
ISI
SICI code
0306-5251(1995)39:2<172:RBOANO>2.0.ZU;2-X
Abstract
The relative bioavailability of cyclosporin A (CsA) from a new microem ulsion oral formulation (NEO) and the currently used soft gelatine cap sule (SGC) was determined at steady state in 12 patients with rheumato id arthritis. The AUC(0,12 h) values of cyclosporin A were significant ly greater after NEO than SGC (2873 +/- 848 ng ml(-1) h (mean +/- s.d. ) vs 2355 +/- 1128 ng ml(-1) h; P = 0.02, 95% Cl (confidence interval of-the difference: 81 to 955 ng ml(-1) h). C-max values were significa ntly higher after NEO than after SGC (811 +/- 244 ng ml(-1) vs 495 +/- 291 ng ml(-1), P < 0.0001, 95% Cl of the difference: 209 to 422 ng ml (-1)).