ALTERATION OF AMMONIA AND CARNITINE LEVELS IN SHORT-TERM TREATMENT WITH PIVALIC ACID-CONTAINING PRODRUG

Citation
T. Ito et al., ALTERATION OF AMMONIA AND CARNITINE LEVELS IN SHORT-TERM TREATMENT WITH PIVALIC ACID-CONTAINING PRODRUG, Tohoku Journal of Experimental Medicine, 175(1), 1995, pp. 43-53
Citations number
26
Categorie Soggetti
Medicine, Research & Experimental
ISSN journal
00408727
Volume
175
Issue
1
Year of publication
1995
Pages
43 - 53
Database
ISI
SICI code
0040-8727(1995)175:1<43:AOAACL>2.0.ZU;2-H
Abstract
We investigated the influence on mitochondrial functions in carnitine deficiency caused by short-term treatment of cefterampivoxil (CFTM-PI) which is one of pivaloyloxymethyl-esterified antibiotics in adult vol unteers and diseased children. Administration of CFTM-PI caused hypoca rnitinemia in all cases, and we observed a significant elevation of bl ood ammonia levels compared with those after its withdrawal in disease d children. A significant negative correlation was found between the l evels of serum free carnitine and blood ammonia, and a positive correl ation was observed between serum carnitine and blood glutamine levels in all adult samples and samples during administration in diseased chi ldren. Our data suggest that these antibiotic medications affect the m itochondrial function even in a short-term treatment and that L-carnit ine supplementation would be necessary for patients treated with CFTM- PI.