As a method of considering only significant radiation doses to differe
nt tissues, the ICRU Report 50 recommends taking the dose given to a s
ignificant tissue volume (minimum diameter greater then 15 mm) instead
of choosing a single, potentially insignificant, voxel value. In orde
r to find this significant volume, we have adapted an emission imaging
analysis method to radiation therapy planning. The resulting method f
inds and characterizes the dose distribution in the volumes of interes
t in a way that includes spatial arrangement. The data can be used to
signal significant hot or cold volumes in the dose plan and to score t
he plans based on significant dose to the tissues.