P. Burgard et al., PSYCHOPATHOLOGY OF PATIENTS TREATED EARLY FOR PHENYLKETONURIA - RESULTS OF THE GERMAN COLLABORATIVE STUDY OF PHENYLKETONURIA, Acta paediatrica, 83, 1994, pp. 108-110
At the age of 13 years, 60 adolescents, suffering from phenylalaninemi
a due to hydroxylase deficiency, and their mothers were simultaneously
investigated with a standardized psychiatric interview in order to de
termine the adolescents' psychiatric status. Forty symptoms related to
emotional disorders, antisocial and conduct disorders, hyperkinetic s
yndromes, and specific symptoms like psychophysiological pains, enures
is, encopresis, ties, stereotypies, and eating disorders were examined
. Severity level was rated as undisturbed, mild, moderate, and severe
disturbance. Comparison with a representative sample of 191 age mates
revealed a double rate of moderate disturbances for the PKU sample. Th
ere was no association between severity level and sex as well as mean
phenylalanine level during the first 13 years of the patients' lives.
No PKU specific diagnosis could be determined. WISC-R-IQ below 90 was
associated with a threefold risk of more severe disturbance and patien
ts with more than three adverse familial circumstances had a 50% chanc
e of getting a psychiatric diagnosis. It is concluded that the observe
d disturbances result from stress associated more with the chronic con
dition than with the increased phenylalanine level.