NERVE GROWTH-FACTOR TREATMENT RESTORES [H-3] QNB BINDING-SITE DENSITYIN ADULT-RAT SUBJECTED TO CORTICAL INFARCTION

Authors
LIBERINI P REUBEN M CLARKE PBS CUELLO AC
Citation
P. Liberini et al., NERVE GROWTH-FACTOR TREATMENT RESTORES [H-3] QNB BINDING-SITE DENSITYIN ADULT-RAT SUBJECTED TO CORTICAL INFARCTION, NeuroReport, 6(3), 1995, pp. 419-420
Citations number
10
Categorie Soggetti
Neurosciences
Journal title
NeuroReport → ACNP
ISSN journal
09594965
Volume
6
Issue
3
Year of publication
1995
Pages
419 - 420
Database
ISI
SICI code
0959-4965(1995)6:3<419:NGTR[Q>2.0.ZU;2-O
Abstract
THE effects of unilateral cortical devascularization and nerve growth factor treatment an muscarinic cholinoceptors labelled with [H-3]QNB w ere investigated in rat cerebral cortex. The lesion induced a signific ant ipsilateral decrease in the density (B-max) but not in the affinit y (k(D)) of [H-3]QNB binding sites. Intraventricular infusion of 2.5 S mouse nerve growth factor (NGF) increased the density of binding site s such that B-max values of lesioned animals treated with NGF were not different from control subjects.