IN-VITRO ACTIVITY OF TAXOL AND TAXOTERE IN COMPARISON WITH DOXORUBICIN AND CISPLATIN ON PRIMARY-CELL CULTURES OF HUMAN BREAST CANCERS

Authors
ZOLI W FLAMIGNI A FRASSINETI GL BAJORKO P DEPAOLA F MILANDRI C AMADORI D GASPERICAMPANI A
Citation
W. Zoli et al., IN-VITRO ACTIVITY OF TAXOL AND TAXOTERE IN COMPARISON WITH DOXORUBICIN AND CISPLATIN ON PRIMARY-CELL CULTURES OF HUMAN BREAST CANCERS, Breast cancer research and treatment, 34(1), 1995, pp. 63-69
Citations number
33
Categorie Soggetti
Oncology
Journal title
Breast cancer research and treatment → ACNP
ISSN journal
01676806
Volume
34
Issue
1
Year of publication
1995
Pages
63 - 69
Database
ISI
SICI code
0167-6806(1995)34:1<63:IAOTAT>2.0.ZU;2-K
Abstract
The in vitro activities of taxol and taxotere in comparison with cispl atin and doxorubicin were assessed in 30 primary tumor cultures from h uman breast cancers. Both taxanes were much more potent than cisplatin and doxorubicin, Taxotere was 3.1; 296, and 9.6-fold more cytotoxic t han taxol, cisplatin, and doxorubicin respectively. The cytotoxic acti vity observed in our experiments confirms the potential clinical relev ance of the two taxanes in the management of breast cancer.