Tm. Neer et Jn. Kornegay, LEUKOENCEPHALOMALACIA AND CEREBRAL WHITE-MATTER VACUOLAR DEGENERATIONIN 2 RELATED LABRADOR RETRIEVER PUPPIES, Journal of veterinary internal medicine, 9(2), 1995, pp. 100-104
Two Labrador Retriever dogs from a common dam had similar neurological
deficits consisting of cortical blindness, dullness, and loss of prev
iously learned habits. Both were examined at 5 months of age, and hist
opathological examination revealed leucoencephalomalacia and vacuolar
degeneration of the cerebral white matter. Histopathologic findings in
these 2 dogs differed from those reported previously in Labrador Retr
ievers with spongy degeneration of central nervous system white matter
. A nonlittermate full sibling to 1 of these dogs was examined at 1.5
years of age for similar clinical signs that did not progress for the
next 25 months.