NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INHIBITORS OF HIV GP120-HUMAN CD4 BINDING

Authors
PATIL AD KUMAR NV KOKKE WC BEAN MF FREYER AJ DEBROSSE C MAI S TRUNEH A FAULKNER DJ CARTE B BREEN AL HERTZBERG RP JOHNSON RK WESTLEY JW POTTS BCM
Citation
Ad. Patil et al., NOVEL ALKALOIDS FROM THE SPONGE BATZELLA SP - INHIBITORS OF HIV GP120-HUMAN CD4 BINDING, Journal of organic chemistry, 60(5), 1995, pp. 1182-1188
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
60
Issue
5
Year of publication
1995
Pages
1182 - 1188
Database
ISI
SICI code
0022-3263(1995)60:5<1182:NAFTSB>2.0.ZU;2-G
Abstract
The Caribbean sponge Batzella sp. contains a number of guanidine alkal oids, two of which, batzelladines A (1) and B (2), inhibit the binding of HIVgp-120 to CD4 and are therefore potential inhibitors of HIV. In addition to the known metabolites ptilomycalin A (6), ptilocaulin (7) , crambescin A (8), crambescidin 800 (9), and crambescidin 816 (10), B atzella sp. contains five new alkaloids, batzelladines A-E (1-5), the structures of which were elucidated by interpretation of spectral data and chemical degradation.