ON THE MECHANISM OF BUFFER-CATALYZED HYDROLYSIS OF RNA MODELS

Authors
PERRIN CL
Citation
Cl. Perrin, ON THE MECHANISM OF BUFFER-CATALYZED HYDROLYSIS OF RNA MODELS, Journal of organic chemistry, 60(5), 1995, pp. 1239-1243
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
60
Issue
5
Year of publication
1995
Pages
1239 - 1243
Database
ISI
SICI code
0022-3263(1995)60:5<1239:OTMOBH>2.0.ZU;2-9
Abstract
An alternative mechanism is proposed for the simultaneous hydrolysis a nd isomerization of 3',5 ''-uridyluridine and related dialkyl phosphat es in aqueous morpholine buffers, which was studied by Breslow and Xu. This alternative mechanism leads to kinetic equations that reproduce the experimental data.