ANTIVIRAL PROTECTIVE IMMUNITY INDUCED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULE-RESTRICTED VIRAL T-LYMPHOCYTE EPITOPES INSERTED IN VARIOUS POSITIONS IN IMMUNOLOGICALLY SELF AND NONSELF PROTEINS
G. Weidt et al., ANTIVIRAL PROTECTIVE IMMUNITY INDUCED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULE-RESTRICTED VIRAL T-LYMPHOCYTE EPITOPES INSERTED IN VARIOUS POSITIONS IN IMMUNOLOGICALLY SELF AND NONSELF PROTEINS, Journal of virology, 69(4), 1995, pp. 2654-2658
Injection into mice of chimeric proteins consisting of a portion of ei
ther the simian virus 40 large tumor antigen or nonstructural protein
1 of influenza A virus or of the murine tumor suppressor p53 on one ha
nd and T-cell epitopes of lymphocytic choriomeningitis virus on the ot
her resulted in antiviral protective immunity, which was independent o
f the epitopes' position in the protein and the same whether the latte
r was immunologically nonself or self. Mice of different haplotypes we
re protected when the corresponding class I molecule-restricted epitop
es had been inserted close to each other in one carrier protein.