ANTIVIRAL PROTECTIVE IMMUNITY INDUCED BY MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I MOLECULE-RESTRICTED VIRAL T-LYMPHOCYTE EPITOPES INSERTED IN VARIOUS POSITIONS IN IMMUNOLOGICALLY SELF AND NONSELF PROTEINS

Injection into mice of chimeric proteins consisting of a portion of ei ther the simian virus 40 large tumor antigen or nonstructural protein 1 of influenza A virus or of the murine tumor suppressor p53 on one ha nd and T-cell epitopes of lymphocytic choriomeningitis virus on the ot her resulted in antiviral protective immunity, which was independent o f the epitopes' position in the protein and the same whether the latte r was immunologically nonself or self. Mice of different haplotypes we re protected when the corresponding class I molecule-restricted epitop es had been inserted close to each other in one carrier protein.