CLINICAL EXAMINATION OF RENAL-FUNCTION IN SHEEP .3. PATHOLOGICAL-CHANGES OF FUNCTION IN NEPHROPATHIES OF SHEEP AND IN UROLITHIASIS OF RAMS AND BILLY-GOATS

Examination of renal function have been carried out in sheep with acut prerenal (n = 6), renal (n = 15) or postrenal failure (n = 3), pyeloc ystitis (n = 4), and in cases of urolithiasis in rams (n = 16) and bil ly goats (n = 11) respectively. The calculation of parameters was done on the basis of the estimated weight dependent endogenous creatinine excretion. A control group of 56 healthy non pregnant or early pregnan t (<120th day of pregnancy) ewes have been used. The renal creatinine clearance was reduced and the absolute as well as the fractional renal water excretion was enhanced in all groups of sick animals. An elevat ed fractional excretion of sodium and phosphate could be seen as well. Functional disturbances could be observed in urolithiasis in like man ner as in acute renal failure. There was proteinuria, glucosuria, exce ssive potassium excretion and often decreased plasma concentration of potassium in both syndromes. A hyperkalemia occurred only in the final state of urolithiasis. No clinical outcome of chronic nephropathies c ould be seen. Mortality of the described acute nephropathies was about 76%. The results of examination were suitable to control the course a nd restitution of renal function. They were not helpful for differenti al diagnosis and prognosis of acut renal failure.