M. Rafieiankopaei et al., CONTRASTING ACTIONS OF ACUTE OR CHRONIC PAROXETINE AND FLUVOXAMINE ONMORPHINE WITHDRAWAL-INDUCED PLACE CONDITIONING, European journal of pharmacology, 275(2), 1995, pp. 185-189
The acute and chronic effects of paroxetine and fluvoxamine on naloxon
e withdrawal-induced place aversion in morphine dependent rats were in
vestigated. Acutely administered fluvoxamine (25 mg/kg s.c. given 30 m
in prior to naloxone withdrawal pairing) and chronic daily paroxetine
(10 mg/kg s.c.) coadministration with a morphine induction protocol, b
oth attenuated morphine withdrawal place aversion. Conversely, acutely
administered paroxetine (up to 25 mg/kg s.c.) or chronic daily fluvox
amine (10 mg/kg s.c.) coadministration with morphine did not modify su
bsequent withdrawal place aversion. Previous radioligand binding studi
es indicate that fluvoxamine has opioid-displacing properties. It is s
uggested therefore that acute fluvoxamine may have decreased withdrawa
l aversion, probably through serotonin and also, in part, via an opioi
d-like mechanism whereas chronic paroxetine decreased withdrawal avers
ion by a serotonergic mechanism, but it is not clear whether opioid sy
stems play any role in the action of paroxetine.