SEROTONIN ANTIBODIES AND THEIR POSSIBLE R OLE IN PARKINSONISM

Serotonin antibodies (SAb) were found in the blood sera of midle-aged and elderly parkinsonian patients. The insidence of Sab in young and m iddle-aged healthy subjects was less, but increasing with age. Injecte d into the rabbit caudate nuclei, Sab the main pathogenetic mechanism of parkinsonian the generator of pathologicaly enhanced excitation (GP EE) and parkinsonian symptoms Induced by the MFP injection into substa ntia nigra. The intracaudate injection of serotonin enhanced Gpee acti vity and parkinsonian syndrome. The role of serotoninergic system and SAb in parkinsonism is discussed.