This paper presents a new methodology which employs physicochemical pr
operties and their relationships to separation techniques for design a
nd synthesis of separation processes. The methodology covers a wide ra
nge of separation problems and consists of selection and identificatio
n of separation techniques (and the corresponding separation tasks), t
he sequencing of the separation tasks and the determination of appropr
iate and consistent conditions of operation. For a specified multicomp
onent separation problem, subsets of feasible separation techniques ar
e first identified for every binary and user-specified separation task
s. The number of alternatives for each separation task is reduced by s
ystematically analyzing the relationships between properties, separati
on technique and conditions of operation. After the final step, an est
imate of the final process flowsheet is produced with a list of possib
le alternatives for the separation tasks. Application of the methodolo
gy is demonstrated through examples highlighting the different steps o
f the methodology.