HEMOSTATIC DISORDERS IN PATIENTS WITH MIT RAL PROLAPSE

Mitral prolapse is frequently encountered in association with other ma nifestations of mesenchymal dysplasia (skin hyperelastosis, joint hype rmobility, dislocations, etc.) and occasional bleedings. Of 35 cases r eported, 17 had petechiae and ecchymoses, 1 had hematuria, the rest su ffered from bleedings: nasal (22 cases), profuse menstrual (19 cases), long-term extraction and cut bleedings (9 cases), gastrointestinal (3 cases), Hemorrhages of different sites often occurred in combination. Hemostatic investigations revealed: platelet aggregation dysfunction, Willebrand syndrome, end coagulation disturbances, lack or anomalies of factors VII, X and II (14, 17, 12 and 4 patients, respectively),