CHRONIC HEPATIC DISEASES - SECONDARY THYM IC INSUFFICIENCY AND IMMUNOCORRECTION WITH TACTIVIN

105 patients with chronic diffuse diseases of the liver were examined clinically, biochemically and immunologically. The examination include d investigation of serum thymic activity, subpopulation of peripheral blood lymphocytes using monoclonal antibodies, immunoglobulins (A, M, G) and CIC, Thymic activity in the serum was low in chronic persistent hepatitis, much lower in chronic active hepatitis and the lowest in h epatic cirrhosis. Thymic activity correlated with the process activity and compensation, peripheral blood levels of T-lymphocytes, T-helpers , T-suppressors, The conclusion is made on thymic deficiency in chroni c diffuse hepatic diseases. Correction of chronic secondary thymic ins ufficiency with tactivin produced a good clinical response.