DISSEMINATED CRYPTOCOCCOSIS IN A PATIENT WITH AIDS

We report the case of a 31-year-old AIDS patient who had generalized c ryptococcal disease with involvement of the lungs, bone marrow, gastro intestinal tract and skin as well as chorioretinitis which may have be en due also to Cryptacoccus neoformans infection. Initially there was no involvement of the central nervous system. The patient recovered af ter 43 days' treatment with fluconazole and amphotericin B and flucyto sine initially. Four months later he presented with a cryptococcal spl enic abscess despite secondary prevention with fluconazole and twice-w eekly liposomal amphotericin B. After splenectomy the patient was disc harged in good health. One year later he died of cryptococcal meningit is.