CONTROLLING THE STEREOCHEMISTRY AT C-15 IN PROSTAGLANDIN SYNTHESIS USING A STEREOCONVERGENT ALLYLSILANE SYNTHESIS AND A SILYL-TO-HYDROXY CONVERSION

Authors
FLEMING I WINTER SBD
Citation
I. Fleming et Sbd. Winter, CONTROLLING THE STEREOCHEMISTRY AT C-15 IN PROSTAGLANDIN SYNTHESIS USING A STEREOCONVERGENT ALLYLSILANE SYNTHESIS AND A SILYL-TO-HYDROXY CONVERSION, Tetrahedron letters, 36(10), 1995, pp. 1733-1734
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
10
Year of publication
1995
Pages
1733 - 1734
Database
ISI
SICI code
0040-4039(1995)36:10<1733:CTSACI>2.0.ZU;2-C
Abstract
The prostaglandin intermediate 2, although giving a mixture of diaster eoisomeric alcohols 3 and 4, is converted in a stereoconvergent route using silyl-cuprate chemistry and silyl-to-hydroxy conversion into the alcohol 10.