POLYSACCHARIDE (ANK-102) FROM POLIANTHES TUBEROSA CELLS DETERIORATES THE RESISTANCE OF MICE TO LISTERIA-MONOCYTOGENES INFECTION

Authors
MAJIMA T OTSUJI K NAGATOMI R KONNO T
Citation
T. Majima et al., POLYSACCHARIDE (ANK-102) FROM POLIANTHES TUBEROSA CELLS DETERIORATES THE RESISTANCE OF MICE TO LISTERIA-MONOCYTOGENES INFECTION, Immunopharmacology and immunotoxicology, 17(1), 1995, pp. 59-68
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Immunopharmacology and immunotoxicology → ACNP
ISSN journal
08923973
Volume
17
Issue
1
Year of publication
1995
Pages
59 - 68
Database
ISI
SICI code
0892-3973(1995)17:1<59:P(FPTC>2.0.ZU;2-6
Abstract
Modulatory effect on the murine self defense system by a newly discove red acidic polysaccharide (ANK-102) produced by P. tuberosa cells in l iquid culture was examined. Pretreatment with ANK-102 deteriorated the murine survival against lethal infection of Listeria monocytogenes, a n intracellular gram-positive bacterium eliminated mainly by macrophag es through T-cell mediated immune response. Pretreatment with ANK-102 resulted in the accumulation of Mac 1 and Mac 2 positive cells in the peritoneal cavity of the infected animals and the reduction of Thy 1.2 expression on the surface of the thymocytes. A new type of immunosupp ressive polysaccharide ANK-102 was introduced.