EMERGENCE OF KARYOTYPICALLY UNRELATED CLONE IN REMISSION OF DE-NOVO ACUTE MYELOBLASTIC LEUKEMIAS

Authors
KUDOH S ASOU H KYO T ASAOKU H DOHY H EGUCHI M TASHIRO S TANAKA K KAMADA N
Citation
S. Kudoh et al., EMERGENCE OF KARYOTYPICALLY UNRELATED CLONE IN REMISSION OF DE-NOVO ACUTE MYELOBLASTIC LEUKEMIAS, British Journal of Haematology, 89(3), 1995, pp. 531-534
Citations number
11
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
89
Issue
3
Year of publication
1995
Pages
531 - 534
Database
ISI
SICI code
0007-1048(1995)89:3<531:EOKUCI>2.0.ZU;2-Q
Abstract
Serial cytogenetic analysis revealed karyotypically unrelated clones i n four patients with acute myeloblastic leukaemia (AML) in remission. At diagnosis, three patients had t(8;21)(q22;q22) and one had an inv(1 6)(p13q22). After 18-22 months in remission, different clones emerged in each patient with myelodysplastic features of the bone marrow cells . The emergence of clones with abnormalities of chromosome 7 in remiss ion seems to be an unfavourable factor for prognosis.