PERSISTENT LYMPHOCYTOSIS OF NATURAL-KILLER-CELLS IN AUTOIMMUNE THROMBOCYTOPENIC PURPURA (ATP) PATIENTS AFTER SPLENECTOMY

Authors
GARCIASUAREZ J PRIETO A REYES E ARRIBALZAGA K PEREZMACHADO MA LOPEZRUBIO M MANZANO L ALVAREZMON M
Citation
J. Garciasuarez et al., PERSISTENT LYMPHOCYTOSIS OF NATURAL-KILLER-CELLS IN AUTOIMMUNE THROMBOCYTOPENIC PURPURA (ATP) PATIENTS AFTER SPLENECTOMY, British Journal of Haematology, 89(3), 1995, pp. 653-655
Citations number
10
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
89
Issue
3
Year of publication
1995
Pages
653 - 655
Database
ISI
SICI code
0007-1048(1995)89:3<653:PLONIA>2.0.ZU;2-D
Abstract
We report three patients with primary autoimmune thrombocytopenic purp ura (ATP) who developed an absolute lymphocytosis (lymphocyte count >5 x10(9)/l) after splenectomy and with a lymphocyte count between 5.4 an d 8.9x10(9)/l. An immunophenotype study showed that the peripheral blo od lymphocytosis was a persistent NK cell expansion (CD2(+), CD56(+), CD3(-)), and was characterized by a typical large granular lymphocytes (LGL) morphology. Two of these ATP patients were refractory to splene ctomy.