HODGKINS-DISEASE ASSOCIATED WITH CHRONIC MYELOID-LEUKEMIA - DETERMINATION OF BCR-ABL REARRANGEMENT IN PARAFFIN-EMBEDDED TUMORS USING THE POLYMERASE CHAIN-REACTION

A patient showing lymph node enlargement and tumors in the neck and ax illa in the course of Philadelphia (Ph(1)) chromosome-positive chronic myeloid leukemia (CML) was seen. There were no hematological findings suggestive of crisis. RNA was isolated from formalin-fixed and paraff in-embedded tissue specimens for the polymerase chain reaction of bcr- abl. CML-type products were detected in the peripheral blood, but no b cr-abl products were found in the lymph nodes. These findings indicate a very rare case in which Hodgkin's disease developed during the cour se of CML.