Background: Vertical rectus muscle injury is commonly cited as a cause
of strabismus after cataract surgery. Injury to the inferior oblique
muscle or nerve as a complication of cataract surgery has not been des
cribed previously. Methods: Four patients without pre-existing strabis
mus who had diplopia after cataract surgery were studied. Analysis inc
luded prism and cover testing, Lancaster red-green testing, and fundus
torsion assessment. Results: Three patients had a delayed-onset hyper
tropia with fundus extorsion in the eye that underwent surgery, which
is consistent with inferior oblique muscle over-action secondary to pr
esumed contracture. The fourth patient had an immediate-onset hypotrop
ia with fundus intorsion in the eye that underwent surgery, which is c
onsistent with inferior oblique muscle paresis. Damage to a vertical r
ectus muscle or ''unmasking'' of a pre-existing superior oblique muscl
e paresis could not explain the history and findings in this group of
four patients. Conclusion: The inferior oblique muscle contracture obs
erved in three patients may have been caused by local anesthetic myoto
xicity, whereas the paresis observed in one patient may have been due
to mechanical trauma or anesthetic toxicity directly to the nerve inne
rvating the muscle. Inferior oblique muscle or nerve injury should be
considered as another possible cause of postoperative strabismus, espe
cially when significant fundus torsion accompanies a vertical deviatio
n.