EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA

Authors
CUTLER N SRAMEK J VEROFF A BLOCK G STAUFFER L LINES C
Citation
N. Cutler et al., EFFECTS OF TREATMENT WITH SIMVASTATIN AND PRAVASTATIN ON COGNITIVE FUNCTION IN PATIENTS WITH HYPERCHOLESTEROLEMIA, British journal of clinical pharmacology, 39(3), 1995, pp. 333-336
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
British journal of clinical pharmacology → ACNP
ISSN journal
03065251
Volume
39
Issue
3
Year of publication
1995
Pages
333 - 336
Database
ISI
SICI code
0306-5251(1995)39:3<333:EOTWSA>2.0.ZU;2-I
Abstract
The effects of equi-efficacious doses of the cholesterol-lowering drug s simvastatin (20 mg day(-1)) and pravastatin (40 mg day(-1)) on tests of cognitive function were investigated in a double-blind, placebo-co ntrolled, 2-period (4 weeks per period), incomplete block, crossover s tudy of 36 patients (24 per treatment) with hypercholesterolaemia. Aft er 4 weeks neither of the active treatments differed significantly fro m placebo on any cognitive measure.