2ND PRIMARY TUMORS IN PATIENTS WITH HEAD AND NECK SQUAMOUS-CELL CARCINOMA

Background. The concept that a patient could develop cancer twice was first put forward by Billroth. Second primary neoplasms are a particul ar feature of head and neck cancer. Methods. This study examines the r ecords of 3436 patients with squamous cell carcinoma of the head and n eck, of whom 274 subsequently developed a second neoplasm. Results. Th e actuarial second primary rate was 9.1% at 372 months, and median tim e to presentation for the second tumor was 36 months. Second tumors we re more likely to occur in male patients younger than 60 years at the time of their index tumor, and who had laryngeal and oral cavity index tumors. Patients whose index tumor was small at diagnosis had a great er chance of developing a second tumor as did those with no cervical l ymph node metastases to the neck. Radiotherapy to the index tumor was not associated with an increased risk of developing a second tumor. Th e commonest sites for second tumors were the head and neck (50%) and t he lung (34%), and 86% were squamous cell carcinomas. The tumor-specif ic mortality for those who developed a second primary tumor was 20% af ter 15 years compared with 44% for patients who did not develop a seco nd primary tumor. The 5-year survival for patients who developed a sec ondary tumor from the time of its diagnosis was 26%. Conclusions. Seco nd primary tumors in the head and neck of patients with cancer are not uncommon. If the second tumor occurs in the head and neck region, the prognosis is reasonably good.