BRAIN METABOLITE CHANGES ON IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM

Authors
GUPTA RK BHATIA V POPTANI H GUJRAL RB
Citation
Rk. Gupta et al., BRAIN METABOLITE CHANGES ON IN-VIVO PROTON MAGNETIC-RESONANCE SPECTROSCOPY IN CHILDREN WITH CONGENITAL HYPOTHYROIDISM, The Journal of pediatrics, 126(3), 1995, pp. 389-392
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
The Journal of pediatrics → ACNP
ISSN journal
00223476
Volume
126
Issue
3
Year of publication
1995
Pages
389 - 392
Database
ISI
SICI code
0022-3476(1995)126:3<389:BMCOIP>2.0.ZU;2-2
Abstract
Localized in vivo proton magnetic resonance spectroscopy and imaging w ere performed in five children with untreated congenital hypothyroidis m to look for biochemical markers of abnormal myelin and neuronal deve lopment, The patients had high levels of choline-containing compounds, which returned to normal with euthyroidism. These metabolic alteratio ns may reflect blocks in myelin maturation that are reversible by thyr oid hormone replacement throughout childhood.