Fx. Keeley et al., DIAGNOSTIC-ACCURACY OF URETEROSCOPIC BIOPSY IN UPPER TRACT TRANSITIONAL-CELL CARCINOMA, The Journal of urology, 157(1), 1997, pp. 33-37
Purpose: Our aim was to determine the accuracy of ureteroscopic biopsi
es and cytological techniques compared to open surgical specimens of u
pper tract transitional cell carcinoma. Materials and Methods: From 19
85 to 1995, 51 cases of upper tract transitional cell carcinoma were d
iagnosed ureteroscopically and distal ureterectomy or nephroureterecto
my was performed. Each patient underwent direct ureteroscopic inspecti
on and biopsy. Fresh samples were delivered to the cytopathology labor
atory, where they were examined using cytospin and smear. A cell block
was prepared when visible tissue was present. Grades of ureteroscopic
biopsies were compared to grades and stages of surgical specimens in
42 cases. Results: Cytological evaluation was positive for malignancy
in 48 of the 51 cases (94.1%). Grading of ureteroscopic specimens was
possible in 42 cases (82.4%). Transitional cell carcinoma grade on ure
teroscopy accurately predicted tumor grade and stage in the surgical s
pecimens. Of 30 low or moderate grade ureteroscopic specimens 27 (90%)
proved to be low or moderate grade transitional cell carcinoma in the
surgical specimens, while 11 of the 12 high grade ureteroscopic speci
mens (91.6%) proved to be high grade transitional cell carcinoma (p <
0.0001). Of 30 low or moderate grade ureteroscopic specimens 26 (86.6%
) had a low stage (Ta or T1) tumor. In contrast, 8 of 12 high grade ur
eteroscopic specimens (66.7%) had invasive tumor (stage T2 or T3) in t
he surgical specimen (p = 0.0006). Conclusions: Ureteroscopic inspecti
on and biopsy combined with cytological techniques provide accurate in
formation regarding grade and stage of upper tract transitional cell c
arcinoma.