LONG-TERM HISTOLOGICAL RESPONSE TO INTRAVENOUS TEFLON AND SILICONE INA RAT MODEL

Particle migration is one of the main concerns raised when implanted p lastics are discussed, especially when used for the endoscopic treatme nt of vesicoureteric reflux in children. To study the histological res ponse to migrated plastic material, we injected particulate plastics ( Teflon and silicone) into the jugular vein of 21 Sprague-Dawley rats, 11 of which were killed at 12 months, 9 at 2 years, and 1 died at 18 m onths. The findings were similar for Teflon and silicone and unchanged after from 1 to 2 years. The plastic particles were seen outside pulm onary vessels, within aggregated multinucleate giant cells, surrounded by only small numbers of other types of inflammatory cells.