PERSPECTIVES ON CHEMOTHERAPEUTIC APPROACHES TO ANTIBIOTIC-RESISTANT BACTERIA

This paper presents an overview of the potential chemotherapeutic appr oaches to antibiotic resistance, what those approaches have achieved, and future avenues of exploration. Chemical modifications of existing agent classes, interference with resistance mechanisms, searches for i nhibitors of novel targets, and alternatives to chemotherapy with low- molecular-weight molecules are discussed. The research focusing on nov el targets and on alternative approaches is most likely to yield break throughs against problem organisms in the future.