ANTIHYPERTENSIVE AND ANTIANGINAL ACTIVITY OF DILREN, CALCIUM-ANTAGONIST WITH PROLONGED ACTION

A 4-week course of dilren under clinical, bicycle exercise, EGG, echo- CC control and 24-hour monitoring of AP was given to 19 subjects with essential hypertension stage I-II and ischemic heart disease. A single dose of the drug (300 mg/day) diminished hypertension and angina pect oris in 79 and 63% of the patients, respectively. A 4-week dilren prod uced a 10-11% decrease in the total peripheral vascular resistance, pr olonged P-Q interval by 0.01-0.02 sec without atrioventricular block i n 26% of the patients, reduced AP measured according to Korotkov by 14 .2/10.5 mm Hg (in awake patients by 12.8/8.4 mm Hg, in sleeping ones b y 8.6/4.5 mm Hg without changes in 24-h AP curve). Side effects occurr ed in 5.3% of the cases and were overcome without discontinuation of t he treatment.